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1 year agoLaptops use a 2.5 inch HDD, most desktop cases are designed to hold a 3.5 inch HDD. You may need a special bracket to hold the drive if the case you plan to use only has 3.5 inch bays.
Some modern cases do also include a 2.5 inch mounting spot due to SSDs using a 2.5 inch form factor.
Generally, PCIe auto negotiates transfer speeds and lanes. Similar to a USB drive. It will probably work, but will be limited to the lowest common transfer speed.